ODCs

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1 OMIM reference -
2 associated genes
11 signs/symptoms

COMMON GENES: 1
COMMON SIGNS: 3

2 OMIM references -
2 associated genes
14 signs/symptoms

Isolated plagiocephaly

Isolated cloverleaf skull syndrome

FGFR3	(UniProt - OMIM)		ERF	(UniProt - OMIM)
TCF12	(UniProt - OMIM)		FGFR3	(UniProt - OMIM)

Citations in the biomedical literature:

Isolated plagiocephaly		Isolated cloverleaf skull syndrome
	Synonym(s): - Non-syndromic unicoronal synostosis - Synostotic plagiocephaly		Synonym(s): - Kleeblattschaedel syndrome

	Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare eye disease - Rare genetic disease		Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: 1-5 / 10 000 Average age onset: neonatal/infancy Average age of death: normal Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: before age 5 Type of inheritance: sporadic

	External references: 1 OMIM reference - No MeSH references		External references: 2 OMIM references - No MeSH references


COMMON SIGNS	- Autosomal dominant inheritance - Intellectual deficit / mental / psychomotor retardation / learning disability - Mid-facial hypoplasia / short / small midface

Isolated plagiocephaly		Isolated cloverleaf skull syndrome
	Very frequent - Facial structural asymmetry / facial hemiatrophy / facial hemihypertrophy - Frontal bossing / prominent forehead - Plagiocephaly Frequent - Abnormal eye movements / oculomotor disorder - Abnormal visual field / hemianopsia / hemianopia / scotoma / visual peripheral rim - Strabismus / squint Occasional - Hearing loss / hypoacusia / deafness - Macrocephaly / macrocrania / megalocephaly / megacephaly		Very frequent - Beaked nose - Depressed premaxillary region / midface - High forehead - Low set ears / posteriorly rotated ears - Proptosis / exophthalmos - Stillbirth / neonatal death Frequent - Abnormal vertebral size / shape - Craniostenosis / craniosynostosis / sutural synostosis - Dysostosis / chondrodysplasia / osteodysplasia / osteochondrosis / skeletal dysplasia - Restricted joint mobility / joint stiffness / ankylosis - Syndactyly of fingers / interdigital palm